On the use of cross-validation for time series predictor evaluation.
#DYNAMIC LIGHT SCATTERING MACHINE MANUAL#
Automated and manual classification of metallic nanoparticles with respect to size and shape by analysis of scanning electron micrographs. Advances and applications of nanophotonic biosensors. MIE scattering dynamic light scattering features selection machine learning micro-particles detection shapley value.Ĭopyright © 2022 He, Wang, Wang, Yu, Zhao, Li, Hussain and Liu.Īltug H., Oh S., Maier S. Therefore, the current study validated the performance of the device, and the given technique can be further applied in clinical applications for the detection of microbial particles. The acquired results showed that the developed system can detect microparticles within the range of 1-4 μm, with detection limit of 0.025 mg/ml. The given method depicted an overall classification accuracy of 95.38%. The results showed higher classification accuracies of 94.41%, 94.20%, and 96.12% for the particle sizes of 1, 2, and 4 μm, respectively. The machine learning classifiers were trained using the features with optimum conditions and the classification accuracies were evaluated.
The power spectrum feature was evaluated from the acquired waveforms, and then recursive feature elimination was utilized to filter the features with the highest correlation. The real-time light scattering signals were collected from each sample for 30 min. In this study, three different spherical microparticles with sizes of 1, 2, and 4 μm were analyzed for the classification. The position of the photosensor was based on the Mie scattering theory to detect the maximum light scattering. The twelve different photosensors were arranged symmetrically surrounding the testing sample to acquire the scattered light. The laser light with a wavelength of 660 nm was directed towards the prepared sample. The device consisted of three major parts: a laser light, an assembly of twelve sensors, and a data acquisition system. In the given study, a prototype has been developed for the rapid detection of particle size using multi-angle dynamic light scattering and a machine learning approach by applying a support vector machine. The rapid classification of micro-particles has a vast range of applications in biomedical sciences and technology.
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